A panoramic view across the whole genome

Study directly targeted areas of the genome with a proprietary single DNA analysis technology

Genomic Vision’s technology opens a new perspective for the structural and functional analysis of the genome

The technology combines Molecular Combing, a proprietary technique to untangle single DNA molecules, with a unique
detection strategy, the Genomic Morse Code. This approach allows the direct visualization of large regions of
interest (3kbp – several Mbp) and offers new ways for the discovery of structural variations and dynamic genomic
events.

Genomic Vision’s solution fulfills an unmet medical and research need by enabling the analysis of large scale genome
changes that are implicated in pathology and remain frequently hidden or inaccurately detected by other
technologies. Our approach opens up novel possibilities to complement existing genetic testing and DNA analysis
methods.

A new outlook for DNA analysis

Genetic information’s contiguity is preserved thanks to combing of intact DNA molecules

  •  Detection of genetic modifications in their context
  •  Accurate haplotype phasing

Hard to sequence regions can be analyzed due to hybridization based mapping

  •  Precise counting of copy number variations
  •  Homologous genes analysis
  •  No ambiguity in mapping results

Direct visualization of DNA structure and genomic events thanks to the single molecule detection

  •  Allelic discrimination
  •  Detection of low frequency variants, mosaicism
  •  Compatibility with heterogeneous samples
  •  Study of DNA dynamics (DNA replication and repair)

Molecular Combing: 
Stretching the genome for single molecule
analysis

DNA is attached to a vinyl silane treated glass carrier and stretched over the surface thanks to the
automated Molecular Combing procedure. Hundreds of genomes are spread on the carrier as megabase-long
linear and parallel fibers, with a uniform stretching factor. Labeled DNA probes can be hybridized on
combed DNA and detected by fluorescence microscopy for direct measurements.

 

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Genomic Morse Code (GMC):  
A unique language to reveal structural variations

This approach allows for the design of different Morse Codes, composed of “dashes and dots”, which are
the combinations of probes of different sizes and colors, each specific to a certain sequence of the
region of interest. Any change in the order, in the size of the probes or the spacing between probes can
be directly visualized and measured on combed DNA to map target genes and detect known or undiscovered
rearrangements. 

 

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A wide range of applications

Rapid and accurate identification of large DNA rearrangements implicated in genetic diseases and cancer.

 Discover applications in Clinical Research and Diagnostics

A complementary method for genomic studies, a novel insight into the structure and function of the genome.

 Discover applications for Life Sciences & Biomarker Discovery

A dedicated platform

A set of state-of-the-art tools that allows for a standardized workflow from sample preparation through Molecular
Combing to data analysis.