FiberProbes® HNPCC 

Our aim is to provide an appropriate tool to researchers working on Hereditary Nonpolyposis Colorectal Cancer (HNPCC)

The HNPCC Genomic Morse Code set allows the identification and characterization of the major structural variations including anomalies occurring in flanking regions of the MMR genes. Thereby, the undetected or improperly characterized complex rearrangements can be clearly identified with the Molecular Combing technology.

By powerful quantitative analysis, this method is likely to detect mutations in the common genomic region of the PMS2 gene with a distinction from its pseudogene.

 

Molecular combing gives you clear results with confident interpretation and visualization of the MMR genes and EPCAM

 

> Learn more about Hereditary Nonpolyposis Colorectal Cancer

Five genes analysis

 Characterization of MLH1-PMS2 and MSH2-EPCAM-MSH6

Full length gene perspective

 Detection of the full length of genes thanks to the direct read-out of long, stretched DNA
 Clear identification of the flanking regions

Comprehensive description of the PMS2 gene

 Apparent distinction of the PMS2 gene and PMS2CL

Detection of rearrangements which may be missed by other technologies

 Physical mapping of hard-to-sequence genomic regions
 Detection of non-reported large rearrangements

Results in correlation with conventional technologies

 Identification and accurate characterization of major structural variations

(For research use only) 

MSH2 gene and its upstream region containing the EPCAM gene

MLH1 gene

MSH6 gene