
FiberProbes ® BRCA
A valuable tool to screen large rearrangements in the BRCA1 and BRCA2 genes for the detection of mutations occurring in Hereditary Breast and Ovarian Cancer (HBOC)

The FiberProbes® for BRCA is a set of Genomic Morse Codes (GMC), developed by Genomic Vision, aims to identify and characterize major rearrangements that affect the BRCA1 and BRCA2 genes. With a specific GMC design, the direct analysis of stretched DNA molecule gives a panoramic view of the BRCA genes and their genomic environment, allowing a high sensitivity detection of large rearrangements.
We have designed high-resolution Genomic Morse Codes covering exons, non-coding sequences and large flanking regions of both BRCA genes

BRCA 1 Genomic Morse Code
Probe and interval sizes are indicated in kb.The complete BRCA1 GMC covers a genomic region of 195 kb and is composed of 15 signals of a distinct color (green, red, or blue). Each signal is composed of one or two single DNA probes. Learn more

BRCA 2 Genomic Morse Code
Probe and interval sizes are indicated in kb.The complete BRCA2 GMC covers a genomic region of 144 kb and is composed of 13 signals of a distinct color (green, red, or blue). Each signal is composed of 2 to 4 single DNA probes. Learn more
The Molecular Combing technology brings a panoramic view of genes and their surrounding regions
this makes it suitable for detecting large BRCA rearrangements
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Distinctive vision
Full length analysis of both BRCA genes
Capacity to cover noncoding regions, promoters and flanking regions
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Accurate visualization of hard-to-sequence genomic regions
Tandem repeats and copy number variations improperly characterized by other processes do not represent an obstacle for the Molecular combing technology
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Detection of unreported genomic rearrangements
The Molecular Combing technology has confirmed new complex structural mutations on both BRCA genes, including the identification of unreported BRCA1 copy number variations
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Precise probe signal measurements
Determine the presence and the nature of copy number variations, deletions or inversion
For research use only
Product | Quantity | Reference |
BRCA Genomic Morse Code set (validated for use with the Molecular Combing Platform) | 10 hybridizations | … |
