FiberProbes ® BRCA

A valuable tool to screen large rearrangements in the BRCA1 and BRCA2 genes for the detection of mutations occurring in Hereditary Breast and Ovarian Cancer (HBOC)

The FiberProbes® for BRCA is a set of Genomic Morse Codes (GMC), developed by Genomic Vision, aims to identify and characterize major rearrangements that affect the BRCA1 and BRCA2 genes. With a specific GMC design, the direct analysis of stretched DNA molecule gives a panoramic view of the BRCA genes and their genomic environment, allowing a high sensitivity detection of large rearrangements.

We have designed high-resolution Genomic Morse Codes covering exons, non-coding sequences and large flanking regions of both BRCA genes

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BRCA 1 Genomic Morse Code 

Probe and interval sizes are indicated in kb.The complete BRCA1 GMC covers a genomic region of 195 kb and is composed of 15 signals of a distinct color (green, red, or blue). Each signal is composed of one or two single DNA probes. Learn more


BRCA 2 Genomic Morse Code

Probe and interval sizes are indicated in kb.The complete BRCA2 GMC covers a genomic region of 144 kb and is composed of 13 signals of a distinct color (green, red, or blue). Each signal is composed of 2 to 4 single DNA probes. Learn more

The Molecular Combing technology brings a panoramic view of genes and their surrounding regions

this makes it suitable for detecting large BRCA rearrangements

  • Distinctive vision

    Full length analysis of both BRCA genes

    Capacity to cover noncoding regions, promoters and flanking regions

 

  • Accurate visualization of hard-to-sequence genomic regions

    Tandem repeats and copy number variations improperly characterized by other processes do not represent an obstacle for the Molecular combing technology

 

  • Detection of unreported genomic rearrangements

    The Molecular Combing technology has confirmed new complex structural mutations on both BRCA genes, including the identification of unreported BRCA1 copy number variations

 

  • Precise probe signal measurements

    Determine the presence and the nature of copy number variations, deletions or inversion 

     

For research use only

Product Quantity Reference
BRCA Genomic Morse Code set (validated for use with the Molecular Combing Platform) 10 hybridizations …